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KMID : 0363320100310020365
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Journal of Korean Oriental Internal Medicine
2010 Volume.31 No. 2 p.365 ~ p.371
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Anti-inflammatory Effect of Jakyakgamcho-tang
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Kim Byung-Woo
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Abstract
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The present study investigated the anti-inflammatory effect of Jakyakgamcho-tang in lipopolysaccharide-exposed rats. The plasma concentration of IL-, IL-6 and TNF- peaked at 5hrs after LPS injection, and these values of the 300 mg/kg Jakyakgamcho-tang group were lower than those of the control group. The plasma concentration of IL-10 peaked at 5hrs after LPS injection and the values of the Jakyakgamcho-tang groups were higher than those of the control group. In the liver cytokines measurement was done at 5hrs after LPS injection. The concentrations of liver IL- and IL-6 in the 300 mg/kg Jakyakgamcho-tang were lower than that of the control group. The concentrations of liver TNF-, and IL-10 showed no significant differences among all the treatment groups. These results indicate that the Jakyakgamcho-tang has anti-inflammatory activities.
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KEYWORD
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Jakyakgamcho-tang, Lipopolysaccharide(LPS), Cytokines, Inflammatory effect
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